High interaction alginate–hyaluronate associations by hyaluronate deacetylation for the preparation of efficient biomaterials
Identifieur interne : 001B66 ( Main/Exploration ); précédent : 001B65; suivant : 001B67High interaction alginate–hyaluronate associations by hyaluronate deacetylation for the preparation of efficient biomaterials
Auteurs : Sandra Oerther [France] ; Anne-Catherine Maurin [France] ; Elisabeth Payan [France] ; Patrick Hubert [France] ; François Lapicque [France] ; Nathalie Presle [France] ; Jean Dexheimer [France] ; Patrick Netter [France] ; Françoise Lapicque [France]Source :
- Biopolymers [ 0006-3525 ] ; 2000-10-05.
Descripteurs français
- Wicri :
- topic : Polymère.
English descriptors
- KwdEn :
- Acetic acid, Alginate, Alginate concentration, Alginate solution, Amide bounds, Amino, Amino groups, Anal biochem, Apparent viscosity, Aqueous solution, Average diameter, Biologie forestiere, Carboxyl groups, Carboxylic, Carboxylic groups, Circular dichroism, Communaute urbaine, Control release, Deacetylated hyaluronate, Deacetylation, Deacetylation extent, Deacetylation rate, Gelation time, Hardness, High temperature, Huggins, Hyaluronate, Hyaluronate association, Hyaluronate associations, Hyaluronate chains, Hyaluronate concentration, Hyaluronate deacetylation, Hyaluronate polysaccharide, Hyaluronate samples, Hyaluronate solutions, Hyaluronates, Hydrazine, Hydrazine sulfate, Intrinsic viscosity, Ionic strength, John wiley sons, Mechanical properties, Moderate deacetylation, Molecular weight, Molecular weights, Nacl concentration, Nacl solution, Native hyaluronate, Oerther, Physiological conditions, Polyelectrolyte effect, Polymer, Polymer association, Polymer interactions, Polymeric chains, Polysaccharide, Reaction time, Rheological, Rheological measurements, Same symbols, Shear rate, Shear stress, Single polymer solutions, Single solutions, Small cavities, Sodium chloride, Sodium tetraborate, Solid lines, Strong interactions, Total concentration, Various hyaluronates, Viscometer, Viscosity group.
- Teeft :
- Acetic acid, Alginate, Alginate concentration, Alginate solution, Amide bounds, Amino, Amino groups, Anal biochem, Apparent viscosity, Aqueous solution, Average diameter, Biologie forestiere, Carboxyl groups, Carboxylic, Carboxylic groups, Circular dichroism, Communaute urbaine, Control release, Deacetylated hyaluronate, Deacetylation, Deacetylation extent, Deacetylation rate, Gelation time, Hardness, High temperature, Huggins, Hyaluronate, Hyaluronate association, Hyaluronate associations, Hyaluronate chains, Hyaluronate concentration, Hyaluronate deacetylation, Hyaluronate polysaccharide, Hyaluronate samples, Hyaluronate solutions, Hyaluronates, Hydrazine, Hydrazine sulfate, Intrinsic viscosity, Ionic strength, John wiley sons, Mechanical properties, Moderate deacetylation, Molecular weight, Molecular weights, Nacl concentration, Nacl solution, Native hyaluronate, Oerther, Physiological conditions, Polyelectrolyte effect, Polymer, Polymer association, Polymer interactions, Polymeric chains, Polysaccharide, Reaction time, Rheological, Rheological measurements, Same symbols, Shear rate, Shear stress, Single polymer solutions, Single solutions, Small cavities, Sodium chloride, Sodium tetraborate, Solid lines, Strong interactions, Total concentration, Various hyaluronates, Viscometer, Viscosity group.
Abstract
The paper presents fundamental investigations of alginate–hyaluronate association with significant polymer interactions for preparation of efficient biomaterials. For this purpose, acetamide functions of hyaluronate were partly cleaved by hydrazine at high temperature, yielding amino groups accessible to carboxylic functions of the alginate chain. Alginate–hyaluronate association was studied both in dissolved state by rheological measurements and CD, and in the form of gel slabs prepared after calcium diffusion. Appreciable interaction between carboxylic groups of alginate and the released amino groups of hyaluronate was put into evidence by enhanced values of the viscosity of mixed solutions, and by assessment of the properties of the gel formed: moderate deacetylation allowed gels of improved hardness and viscosity. Nevertheless, high deacetylation was observed to hinder the gel formation by Ca2+ complexation of alginate, by the significant competition of COOH–NH2 association. Interaction between alginate and modified hyaluronate results in regular gel structure, with small cavities. © 2000 John Wiley & Sons, Inc. Biopoly 54: 273–281, 2000
Url:
DOI: 10.1002/1097-0282(20001005)54:4<273::AID-BIP40>3.0.CO;2-I
Affiliations:
- France
- Grand Est, Lorraine (région)
- Nancy, Vandoeuvre les Nancy, Vandœuvre les Nancy
- Centre national de la recherche scientifique, Laboratoire réactions et génie des procédés, Université de Lorraine
Links toward previous steps (curation, corpus...)
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- to stream Istex, to step Curation: 000181
- to stream Istex, to step Checkpoint: 000712
- to stream Main, to step Merge: 001E83
- to stream Main, to step Curation: 001B66
Le document en format XML
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last="Maurin">Anne-Catherine Maurin</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS–UHP Nancy 1, and FR CNRS W0070, Faculté de Médecine, BP 184, 54505 Vandœuvre les Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre les Nancy</settlement></placeName></affiliation></author><author><name sortKey="Payan, Elisabeth" sort="Payan, Elisabeth" uniqKey="Payan E" first="Elisabeth" last="Payan">Elisabeth Payan</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS–UHP Nancy 1, and FR CNRS W0070, Faculté de Médecine, BP 184, 54505 Vandœuvre les Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine 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xml:lang="fr">France</country><wicri:regionArea>Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS–UHP Nancy 1, and FR CNRS W0070, Faculté de Médecine, BP 184, 54505 Vandœuvre les Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre les Nancy</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Correspondence address: Laboratoire de Pharmacologie, UMR 7561 CNRS–UHP, Faculté de Médecine, BP 184 F‐54505 Vandoeuvre les Nancy Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandoeuvre les Nancy</settlement></placeName></affiliation></author><author><name sortKey="Lapicque, Francoise" sort="Lapicque, Francoise" uniqKey="Lapicque F" first="Françoise" last="Lapicque">Françoise Lapicque</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS–UHP Nancy 1, and FR CNRS W0070, Faculté de Médecine, BP 184, 54505 Vandœuvre les Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre les Nancy</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Biopolymers</title><title level="j" type="alt">BIOPOLYMERS</title><idno type="ISSN">0006-3525</idno><idno type="eISSN">1097-0282</idno><imprint><biblScope unit="vol">54</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="273">273</biblScope><biblScope unit="page" to="281">281</biblScope><biblScope unit="page-count">9</biblScope><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-10-05">2000-10-05</date></imprint><idno type="ISSN">0006-3525</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-3525</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetic acid</term><term>Alginate</term><term>Alginate concentration</term><term>Alginate solution</term><term>Amide bounds</term><term>Amino</term><term>Amino groups</term><term>Anal biochem</term><term>Apparent viscosity</term><term>Aqueous solution</term><term>Average diameter</term><term>Biologie forestiere</term><term>Carboxyl groups</term><term>Carboxylic</term><term>Carboxylic groups</term><term>Circular dichroism</term><term>Communaute urbaine</term><term>Control release</term><term>Deacetylated hyaluronate</term><term>Deacetylation</term><term>Deacetylation extent</term><term>Deacetylation rate</term><term>Gelation time</term><term>Hardness</term><term>High temperature</term><term>Huggins</term><term>Hyaluronate</term><term>Hyaluronate association</term><term>Hyaluronate associations</term><term>Hyaluronate chains</term><term>Hyaluronate concentration</term><term>Hyaluronate deacetylation</term><term>Hyaluronate polysaccharide</term><term>Hyaluronate samples</term><term>Hyaluronate solutions</term><term>Hyaluronates</term><term>Hydrazine</term><term>Hydrazine sulfate</term><term>Intrinsic viscosity</term><term>Ionic strength</term><term>John wiley sons</term><term>Mechanical properties</term><term>Moderate deacetylation</term><term>Molecular weight</term><term>Molecular weights</term><term>Nacl concentration</term><term>Nacl solution</term><term>Native hyaluronate</term><term>Oerther</term><term>Physiological conditions</term><term>Polyelectrolyte effect</term><term>Polymer</term><term>Polymer association</term><term>Polymer interactions</term><term>Polymeric chains</term><term>Polysaccharide</term><term>Reaction time</term><term>Rheological</term><term>Rheological measurements</term><term>Same symbols</term><term>Shear rate</term><term>Shear stress</term><term>Single polymer solutions</term><term>Single solutions</term><term>Small cavities</term><term>Sodium chloride</term><term>Sodium tetraborate</term><term>Solid lines</term><term>Strong interactions</term><term>Total concentration</term><term>Various hyaluronates</term><term>Viscometer</term><term>Viscosity group</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acetic acid</term><term>Alginate</term><term>Alginate concentration</term><term>Alginate solution</term><term>Amide bounds</term><term>Amino</term><term>Amino groups</term><term>Anal biochem</term><term>Apparent viscosity</term><term>Aqueous solution</term><term>Average diameter</term><term>Biologie forestiere</term><term>Carboxyl groups</term><term>Carboxylic</term><term>Carboxylic groups</term><term>Circular dichroism</term><term>Communaute urbaine</term><term>Control release</term><term>Deacetylated hyaluronate</term><term>Deacetylation</term><term>Deacetylation extent</term><term>Deacetylation rate</term><term>Gelation time</term><term>Hardness</term><term>High temperature</term><term>Huggins</term><term>Hyaluronate</term><term>Hyaluronate association</term><term>Hyaluronate associations</term><term>Hyaluronate chains</term><term>Hyaluronate concentration</term><term>Hyaluronate deacetylation</term><term>Hyaluronate polysaccharide</term><term>Hyaluronate samples</term><term>Hyaluronate solutions</term><term>Hyaluronates</term><term>Hydrazine</term><term>Hydrazine sulfate</term><term>Intrinsic viscosity</term><term>Ionic strength</term><term>John wiley sons</term><term>Mechanical properties</term><term>Moderate deacetylation</term><term>Molecular weight</term><term>Molecular weights</term><term>Nacl concentration</term><term>Nacl solution</term><term>Native hyaluronate</term><term>Oerther</term><term>Physiological conditions</term><term>Polyelectrolyte effect</term><term>Polymer</term><term>Polymer association</term><term>Polymer interactions</term><term>Polymeric chains</term><term>Polysaccharide</term><term>Reaction time</term><term>Rheological</term><term>Rheological measurements</term><term>Same symbols</term><term>Shear rate</term><term>Shear stress</term><term>Single polymer solutions</term><term>Single solutions</term><term>Small cavities</term><term>Sodium chloride</term><term>Sodium tetraborate</term><term>Solid lines</term><term>Strong interactions</term><term>Total concentration</term><term>Various hyaluronates</term><term>Viscometer</term><term>Viscosity group</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Polymère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The paper presents fundamental investigations of alginate–hyaluronate association with significant polymer interactions for preparation of efficient biomaterials. For this purpose, acetamide functions of hyaluronate were partly cleaved by hydrazine at high temperature, yielding amino groups accessible to carboxylic functions of the alginate chain. Alginate–hyaluronate association was studied both in dissolved state by rheological measurements and CD, and in the form of gel slabs prepared after calcium diffusion. Appreciable interaction between carboxylic groups of alginate and the released amino groups of hyaluronate was put into evidence by enhanced values of the viscosity of mixed solutions, and by assessment of the properties of the gel formed: moderate deacetylation allowed gels of improved hardness and viscosity. Nevertheless, high deacetylation was observed to hinder the gel formation by Ca2+ complexation of alginate, by the significant competition of COOH–NH2 association. Interaction between alginate and modified hyaluronate results in regular gel structure, with small cavities. © 2000 John Wiley & Sons, Inc. Biopoly 54: 273–281, 2000</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Grand Est</li><li>Lorraine (région)</li></region><settlement><li>Nancy</li><li>Vandoeuvre les Nancy</li><li>Vandœuvre les Nancy</li></settlement><orgName><li>Centre national de la recherche scientifique</li><li>Laboratoire réactions et génie des procédés</li><li>Université de Lorraine</li></orgName></list><tree><country name="France"><region name="Grand Est"><name sortKey="Oerther, Sandra" sort="Oerther, Sandra" uniqKey="Oerther S" first="Sandra" last="Oerther">Sandra Oerther</name></region><name sortKey="Dexheimer, Jean" sort="Dexheimer, Jean" uniqKey="Dexheimer J" first="Jean" last="Dexheimer">Jean Dexheimer</name><name sortKey="Hubert, Patrick" sort="Hubert, Patrick" uniqKey="Hubert P" first="Patrick" last="Hubert">Patrick Hubert</name><name sortKey="Lapicque, Francois" sort="Lapicque, Francois" uniqKey="Lapicque F" first="François" last="Lapicque">François Lapicque</name><name sortKey="Lapicque, Francoise" sort="Lapicque, Francoise" uniqKey="Lapicque F" first="Françoise" last="Lapicque">Françoise Lapicque</name><name sortKey="Maurin, Anne Atherine" sort="Maurin, Anne Atherine" uniqKey="Maurin A" first="Anne-Catherine" last="Maurin">Anne-Catherine Maurin</name><name sortKey="Netter, Patrick" sort="Netter, Patrick" uniqKey="Netter P" first="Patrick" last="Netter">Patrick Netter</name><name sortKey="Netter, Patrick" sort="Netter, Patrick" uniqKey="Netter P" first="Patrick" last="Netter">Patrick Netter</name><name sortKey="Netter, Patrick" sort="Netter, Patrick" uniqKey="Netter P" first="Patrick" last="Netter">Patrick Netter</name><name sortKey="Payan, Elisabeth" sort="Payan, Elisabeth" uniqKey="Payan E" first="Elisabeth" last="Payan">Elisabeth Payan</name><name sortKey="Presle, Nathalie" sort="Presle, Nathalie" uniqKey="Presle N" first="Nathalie" last="Presle">Nathalie Presle</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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